APOBEC3 PROTEINS: HIV DEFENDERS LOST TO TIME
A mock Scientific American spread on the APOBEC3 family, which consists of cytidine deaminases that target viral single-stranded DNA. In short, these proteins mutate the DNA intermediates of retroviruses such as HIV, and stops their replication cycle. It is an evolved host defense against retroviral infection, however HIV has long evolved its own counter against it. All infectious HIV virions contain Vif protein, which tags APOBEC3 for degradation by the hosts's own cellular machinery.
Client: Prof. Derek Ng
Media: Chimera, Pixologic ZBrush, Autodesk Maya, Adobe Photoshop, Adobe Illustrator
Format: Magazine spread
Audience: Educated lay audience
Date: July 2019
(More details coming soon!)